Prof & Doc
Prof & Doc’s watercress serum is a urease-inhibiting, ammonia scavenging, anti-inflammatory, sterile watercress extract designed to counteract incontinence associated dermatitis.
Inhibits urease and scavenges ammonia with a novel anti-inflammatory function. Cosmetic trials for anti-aging, trans-epidermal water loss, redness reduction and more are currently being explored.
Current strategies against incontinence associated dermatitis are focussed on absorption and barrier function which are often ineffective. We target the primary virulence factor, urease, with a natural solution.
Details
Prof & Doc’s watercress serum is the first brand and product launch from Watercress Research Ltd.
Based on 7 years of research, Professor Paul Winyard (Exeter University) and Dr Kyle Stewart (Devon GP) have created a patent pending Watercress extract with unique properties to counteract incontinence associated dermatitis (termed nappy rash in infants).
The major driver incontinence associated dermatitis is the effect of ammonia which causes an alkaline chemical burn. Ammonia is created through The activity of the bacterial urease enzyme. Prof & Doc’s watercress serum contains potent urease inhibitors naturally found in watercress, along with ammonia scavenging capability and a novel anti-inflammatory function.
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Current strategies to manage incontinence associated dermatitis are outdated, focussing on absorption away from the skin, or barrier protection.
Unfortunately, the volatile ammonia gas produced through urease activity can overcome these defences.
At some point in their life, it is believed every infant will suffer at least one episode of nappy rash, leading to irritability, poor feeding, susceptibility to infection and parental stress.
In the frail and elderly population, incontinence associated dermatitis can also lead to bed sores, pain and delirium.
We are the first company to target the major virulence factor, urease, and we are able to do this with a natural product with 3 distinct features.
Evidence
- in-vitro data of our extract’s skin soothing function through Tissue viability tests using artificial skin testing through the company Labskin.
- independent verification of anti-inflammatory function from ADSL - a formulation chemistry company for the cosmetic industry
- computational 3D docking studies of some of our urease inhibitors from watercress in collaboration with the University of Bath
- Urease inhibition studies of multiple extracts carried out by York Biorenewable Development Centre.
- on-going clinical trials through ADSL
